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To install this package, start R and enter:
## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("normalize450K")
In most cases, you don't need to download the package archive at all.
normalize450K
|
This package is for version 3.3 of Bioconductor; for the stable, up-to-date release version, see normalize450K.
Preprocessing of Illumina Infinium 450K data
Bioconductor version: 3.3
Precise measurements are important for epigenome-wide studies investigating DNA methylation in whole blood samples, where effect sizes are expected to be small in magnitude. The 450K platform is often affected by batch effects and proper preprocessing is recommended. This package provides functions to read and normalize 450K '.idat' files. The normalization corrects for dye bias and biases related to signal intensity and methylation of probes using local regression. No adjustment for probe type bias is performed to avoid the trade-off of precision for accuracy of beta-values.
Author: Jonathan Alexander Heiss
Maintainer: Jonathan Alexander Heiss <jonathan.heiss at posteo.de>
Citation (from within R,
enter citation("normalize450K")):
Installation
To install this package, start R and enter:
## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("normalize450K")
Documentation
To view documentation for the version of this package installed in your system, start R and enter:
browseVignettes("normalize450K")
| R Script | Normalization of 450K data | |
| Reference Manual | ||
| Text | LICENSE |
Details
| biocViews | DNAMethylation, MethylationArray, Microarray, Normalization, Preprocessing, Software, TwoChannel |
| Version | 1.0.0 |
| In Bioconductor since | BioC 3.3 (R-3.3) (< 6 months) |
| License | BSD_2_clause + file LICENSE |
| Depends | R (>= 3.3), Biobase, illuminaio, quadprog |
| Imports | utils |
| LinkingTo | |
| Suggests | |
| SystemRequirements | |
| Enhances | |
| URL | |
| Depends On Me | |
| Imports Me | |
| Suggests Me | |
| Build Report |
Package Archives
Follow Installation instructions to use this package in your R session.
| Package Source | normalize450K_1.0.0.tar.gz |
| Windows Binary | normalize450K_1.0.0.zip |
| Mac OS X 10.9 (Mavericks) | normalize450K_1.0.0.tgz |
| Subversion source | (username/password: readonly) |
| Git source | https://github.com/Bioconductor-mirror/normalize450K/tree/release-3.3 |
| Package Short Url | http://bioconductor.org/packages/normalize450K/ |
| Package Downloads Report | Download Stats |
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